Type 2 diabetes patients transplanted with own bone marrow stem cells reduces insulin use

Public release date: 28-Jun-2013
[ | E-mail | Share ]

Contact: Robert Miranda
cogcomm@aol.com
Cell Transplantation Center of Excellence for Aging and Brain Repair

Putnam Valley, NY. (June 28 2013) A study carried out in India examining the safety and efficacy of self-donated (autologous), transplanted bone marrow stem cells in patients with type 2 diabetes (TD2M), has found that patients receiving the transplants, when compared to a control group of TD2M patients who did not receive transplantation, required less insulin post-transplantation.

The study appears as an early e-publication for the journal Cell Transplantation, and is now freely available on-line at http://www.ingentaconnect.com/content/cog/ct/pre-prints/ct0920bhansali.

"There is growing interest in the scientific community for cellular therapies that use bone marrow-derived cells for the treatment of type 2 diabetes mellitus and its complications," said study corresponding author Anil Bhansali, PhD professor and head of the Endocrinology Department at the Post Graduate Institute of Medical Education in Chandrigarh, India. "But the potential of stem cell therapy for this disease is yet to be fully explored."

While there is growing interest in using stem cell transplantation to treat TD2M, few studies have examined the utility of bone marrow-derived stem cells. By experimenting with bone marrow-derived stem cells, the researchers sought to exploit the rich source of stem cells in bone marrow.

Their study aimed at evaluating the efficacy and safety of autologous bone marrow-derived stem cell transplantation in patients with T2DM and who also had good glycemic control. Good glycemic control emerged as an important factor in the transplantation group and in the non-transplanted control group.

Cell transplantation had a significant impact on the patients in this study as those administered cells demonstrated a significant reduction in insulin requirement. A significantly smaller reduction in the insulin requirement of the control group was also observed but a "repeated emphasis on life style modification" was believed to be a contributing factor in this effect.

According to Dr. Bhansali, the strength of their study included the inclusion of a homogenous patient population with T2DM which exhibited good glycemic control, and the presence of a similar control group that did not get cell transplants.

"The efficacy and safety of stem cell therapy needs to be established in a greater number of patients and with a longer duration follow-up," concluded Bhansali and his co-authors. "The data available so far from animal and human studies is encouraging, however, it has enormous limitations."

The researchers recommended determining which type of stem cells -hematopoietic, bone marrow or placenta-derived - might be best to treat T2DM. In addition, they said that post-transplantation patients needed close monitoring for the development of neoplasia as stem cells - whether multipotent or pluripotent - have the potential for malignant transformation.

They concluded that "autologous bone marrow-derived stem cell therapy in patients with T2DM results in significant decrease in insulin dose requirement."

###

Contact:

Dr. Anil Bhansali
Email: anilbhansaliendocrine@rediffmail.com

Citation: Bhansali, A.; Asokumra,P.; Walia, R.; Bhansali, S.; Gupta, V.; Jain, A.; Sachdeva, N.; Sharma, R. R.; Marwaha, N.; Khandelwal, N. Efficacy and Safety of Autologous Bone Marrow Derived Stem Cell Transplantation in patients with Type 2 Diabetes mellitus: A randomized placebo-controlled study. Cell Transplantation.

Appeared or available online: April 2, 2013

The Coeditors-in-chief for CELL TRANSPLANTATION are at the Diabetes Research Institute, University of Miami Miller School of Medicine and Center for Neuropsychiatry, China Medical University Hospital, TaiChung, Taiwan. Contact, Camillo Ricordi, MD at ricordi@miami.edu or Shinn-Zong Lin, MD, PhD at shinnzong@yahoo.com.tw or David Eve, PhD at celltransplantation@gmail.com

News release by Florida Science Communications http://www.sciencescribe.net

---

[ | E-mail | Share ]

?

AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Public release date: 28-Jun-2013
[ | E-mail | Share ]

Contact: Robert Miranda
cogcomm@aol.com
Cell Transplantation Center of Excellence for Aging and Brain Repair

Putnam Valley, NY. (June 28 2013) A study carried out in India examining the safety and efficacy of self-donated (autologous), transplanted bone marrow stem cells in patients with type 2 diabetes (TD2M), has found that patients receiving the transplants, when compared to a control group of TD2M patients who did not receive transplantation, required less insulin post-transplantation.

The study appears as an early e-publication for the journal Cell Transplantation, and is now freely available on-line at http://www.ingentaconnect.com/content/cog/ct/pre-prints/ct0920bhansali.

"There is growing interest in the scientific community for cellular therapies that use bone marrow-derived cells for the treatment of type 2 diabetes mellitus and its complications," said study corresponding author Anil Bhansali, PhD professor and head of the Endocrinology Department at the Post Graduate Institute of Medical Education in Chandrigarh, India. "But the potential of stem cell therapy for this disease is yet to be fully explored."

While there is growing interest in using stem cell transplantation to treat TD2M, few studies have examined the utility of bone marrow-derived stem cells. By experimenting with bone marrow-derived stem cells, the researchers sought to exploit the rich source of stem cells in bone marrow.

Their study aimed at evaluating the efficacy and safety of autologous bone marrow-derived stem cell transplantation in patients with T2DM and who also had good glycemic control. Good glycemic control emerged as an important factor in the transplantation group and in the non-transplanted control group.

Cell transplantation had a significant impact on the patients in this study as those administered cells demonstrated a significant reduction in insulin requirement. A significantly smaller reduction in the insulin requirement of the control group was also observed but a "repeated emphasis on life style modification" was believed to be a contributing factor in this effect.

According to Dr. Bhansali, the strength of their study included the inclusion of a homogenous patient population with T2DM which exhibited good glycemic control, and the presence of a similar control group that did not get cell transplants.

"The efficacy and safety of stem cell therapy needs to be established in a greater number of patients and with a longer duration follow-up," concluded Bhansali and his co-authors. "The data available so far from animal and human studies is encouraging, however, it has enormous limitations."

The researchers recommended determining which type of stem cells -hematopoietic, bone marrow or placenta-derived - might be best to treat T2DM. In addition, they said that post-transplantation patients needed close monitoring for the development of neoplasia as stem cells - whether multipotent or pluripotent - have the potential for malignant transformation.

They concluded that "autologous bone marrow-derived stem cell therapy in patients with T2DM results in significant decrease in insulin dose requirement."

###

Contact:

Dr. Anil Bhansali
Email: anilbhansaliendocrine@rediffmail.com

Citation: Bhansali, A.; Asokumra,P.; Walia, R.; Bhansali, S.; Gupta, V.; Jain, A.; Sachdeva, N.; Sharma, R. R.; Marwaha, N.; Khandelwal, N. Efficacy and Safety of Autologous Bone Marrow Derived Stem Cell Transplantation in patients with Type 2 Diabetes mellitus: A randomized placebo-controlled study. Cell Transplantation.

Appeared or available online: April 2, 2013

The Coeditors-in-chief for CELL TRANSPLANTATION are at the Diabetes Research Institute, University of Miami Miller School of Medicine and Center for Neuropsychiatry, China Medical University Hospital, TaiChung, Taiwan. Contact, Camillo Ricordi, MD at ricordi@miami.edu or Shinn-Zong Lin, MD, PhD at shinnzong@yahoo.com.tw or David Eve, PhD at celltransplantation@gmail.com

News release by Florida Science Communications http://www.sciencescribe.net

---

[ | E-mail | Share ]

?

AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Source: http://www.eurekalert.org/pub_releases/2013-06/ctco-t2d062813.php

anchorman sequel safety not guaranteed lifehouse

Federal decisiveness thrives, for a week at least

WASHINGTON (AP) ? For all the talk of Washington gridlock, the three branches of government are asserting their powers this week, and sometimes surprising their closest observers.

The Supreme Court kept affirmative action alive on college campuses and cleared the way for gay married couples to get federal benefits. A compromise-crafting Senate passed major immigration legislation. And President Barack Obama issued long-awaited orders to combat climate change.

It's possible these events will ultimately amount to little. The House might stifle the immigration bill, for instance. And the Supreme Court ordered a lower court to look hard at colleges' consideration of race when recruiting students.

Still, the first week of summer proved that all facets of the federal government still pack punches, even in a capital riven by partisanship.

The Supreme Court decisions caused the biggest stirs. The justices infuriated conservative lawmakers by overturning the federal Defense of Marriage Act.

At least as surprising was the decision on affirmative action, which some legal scholars had expected the Supreme Court to curtail severely. The NAACP said it was "pleased that the court chose to affirm that there is a place for race in university admissions."

Others, however, said affirmative action won little more than a reprieve, because new waves of legal challenges to race-conscious admissions seem imminent. And later, the NAACP and other liberal groups expressed dismay at another Supreme Court ruling, which nullified key elements of the Voting Rights Act.

Obama, meanwhile, acknowledged that Congress can reach no agreements on climate change, and announced his own plans to limit heat-trapping gases from coal-fired power plants. Using executive powers, the president laid out the first-ever federal regulations on carbon dioxide emitted by existing power plants, which is partly blamed for global warming and rising sea levels.

Republicans and numerous business groups immediately denounced him. It was a reminder -- as if anyone needed it -- of why it's hard for the federal government to take major steps on the environment and many other fields.

"It is astonishing that President Obama is unilaterally imposing new regulations that will cost jobs and increase energy prices," said House Speaker John Boehner, R-Ohio.

Environmental groups welcomed the president's moves, even as they called them long overdue. Environmental activists have grown increasingly frustrated since 2009 as they watched Obama place health care, Wall Street reform, immigration and other priorities ahead of curbing greenhouse gases.

The 2009-2010 congressional struggle to enact Obama's health care overhaul exacerbated Washington's already-intense partisanship. By late 2010 -- when tea party-backed Republicans regained control of the House -- antagonism between the parties grew so heated that once-routine tasks became major chores.

Since then in fact, some of Congress' most consequential actions essentially resulted from the inability to agree on anything. Decision-by-indecision became Washington's new operating method.

In 2011, Senate Republicans devised a strategy that effectively washed Congress' hands of any role in raising the federal debt limit.

Then, when lawmakers struggled for bipartisan spending agreements, they tried to jump-start negotiations by establishing severe national consequences if talks ultimately failed. The talks failed nonetheless, and the once unthinkable consequences -- the "fiscal cliff" tax hikes and "sequestration" spending cuts -- became law this year.

Not terribly long ago, Democrats and Republicans reached agreements to enact budgets, raise the debt limit, pass farm bills and do hundreds of other tasks. Now, bipartisan accords on almost anything will turn heads.

"We have an historic opportunity here in the Senate," Sen. Richard Durbin, D-Ill., said on the chamber floor Tuesday. He was speaking of the immigration bill that would tighten border security and grant pathways to citizenship for people here illegally.

"It doesn't happen very often," Durbin said. "A bipartisan bill! How about that?"

Some Americans, however, see bipartisanship as a betrayal of political principles.

"Primary Rubio!" someone shouted at a recent tea party rally at the Capitol. He was calling for a Republican primary challenge to Sen. Marco Rubio, the Florida Republican once seen as a tea party hero, and an author of the bipartisan Senate immigration plan.

The outbreak of robust government actions might not last. Congress is in recess next week, and many people expect a tough road for the immigration legislation in the Republican-controlled House when lawmakers return to Washington.

And Obama -- already accused of not using his presidential powers to inspire enough fear and friendships to advance his agenda -- may find his clout further reduced. The Supreme Court has agreed to consider whether the president violated the Constitution when he bypassed the Senate to appoint three people to the National Labor Relations Board.

---

Follow Charles Babington on Twitter: https://twitter.com/cbabington.

Source: http://news.yahoo.com/federal-decisiveness-thrives-week-least-183948937.html

nfl wes welker Conclave tmz Sizzurp the bachelor What is a Jesuit

Nokia will pay you up to $300 to trade an old phone for a Lumia

Nokia's Lumia phones show promise despite the company's dwindling overall sales, and now's your chance to nab one at more affordable prices -- if you're willing to trade in an old phone, that is. The Finnish company's new trade up program in the US will take in old mobile devices and send back up to $300 loaded on a Visa prepaid card, so long as you also purchase a Lumia. A lot of brands and models are accepted (check out if yours is via the trade up portal linked below), but popular ones like the iPhone 4S, the Galaxy S 4, and the HTC One will net you the most money. So, if you're sick of being lost in a crowd of Androids and iPhones, now's the time to give WP8 a whirl.

Filed under: Cellphones, Mobile, Nokia

Comments

Source: Nokia 1, 2

Source: http://www.engadget.com/2013/06/28/nokia-trade-up-program/?utm_medium=feed&utm_source=Feed_Classic&utm_campaign=Engadget

true blood Magna Carta Holy Grail nigella lawson fathers day Mac WWE

GIFs of the Week: June 24-28, 2013

All WWE programming, talent names, images, likenesses, slogans, wrestling moves, trademarks, logos and copyrights are the exclusive property of WWE, Inc. and its subsidiaries. All other trademarks, logos and copyrights are the property of their respective owners. ? 2013 WWE, Inc. All Rights Reserved. This website is based in the United States. By submitting personal information to this website you consent to your information being maintained in the U.S., subject to applicable U.S. laws. U.S. law may be different than the law of your home country. WrestleMania XXIX (NY/NJ) logo TM & ? 2013 WWE. All Rights Reserved. The Empire State Building design is a registered trademark and used with permission by ESBC.

Source: http://www.wwe.com/inside/gifs-of-the-week-june-24-28-2013

Michelle Jenneke batman Colorado Shooting News joe paterno British Open MC Chris Colorado shooting suspect

Violence kills 27 in minority region of west China

BEIJING (AP) ? Knife-wielding assailants attacked police and other people at a remote town in China's restive far western region early Wednesday in violence that killed 27 people, one of the bloodiest incidents since unrest in the regional capital killed nearly 200 in 2009.

The early-morning violence ? described by state media as riots ? also left at least three people injured in the Turkic-speaking Xinjiang (shihn-jahng) region, the official Xinhua News Agency said. Police stations, a government building and a construction site were targeted in the attacks, the report said.

Xinhua said 17 people were killed, including nine policemen, before police shot and killed 10 of the assailants in Lukqun, a township in Turpan prefecture. The agency cited officials with the region's Communist Party committee.

Xinjiang is home to a large population of minority Muslim Uighurs (WEE'-gurs) but is ruled by China's Han ethnic majority. The region borders Central Asia, Afghanistan and Pakistan and has been the scene of numerous violent incidents in recent years, including the ethnic riots four years ago in Urumqi, the regional capital.

Xinhua did not provide details about the cause of the unrest and it was impossible to independently confirm the report. Information is tightly controlled in the region, which the Chinese government regards as highly sensitive and where it has imposed a heavy security presence to quell unrest. However, forces are spread thin across the vast territory and the response from authorities is often slow.

An official reached by phone at the press office of the Xinjiang Public Security Bureau, the region's police, said she had only seen news of the violence on the Internet and had no information. Other officials at the county's propaganda department and police said they also had no details. Calls to the region's government spokeswoman, Hou Hanmin, rang unanswered.

Though it remained unclear what caused Wednesday's violence, police stations, government offices and other symbols of Han Chinese authority have been targets of attacks in the past. The attack occurred at 6 a.m. local time, when most residents would still be asleep.

The report said three assailants were seized, and that police pursued fleeing suspects, though it did not say how many. It said three people were injured by the unrest and were being treated.

An overseas Uighur activist said the conflict was triggered by the Chinese government's "sustained repression and provocation" of the Uighur community. Dilxat Raxit, spokesman for the Germany-based World Uyghur Congress, urged the international community to pressure China to "stop imposing policies in Xinjiang that cause turmoil."

China often accuses overseas Uighur activists of orchestrating violent incidents and obscure militant groups sometimes take responsibility, with little or no evidence to prove claims on either side.

Source: http://news.yahoo.com/violence-kills-27-minority-region-west-china-073509508.html

orioles Sarah Jones chicago marathon Johnny Depp Dead college football rankings Steel Magnolias Niels Bohr

Gay marriage gets big boost in two Supreme Court rulings

By Lawrence Hurley

WASHINGTON (Reuters) - The U.S. Supreme Court delivered a landmark victory for gay rights on Wednesday by forcing the federal government to recognize same-sex marriages in states where it is legal and paving the way for it in California, the most populous state.

As expected, however, the court fell short of a broader ruling endorsing a fundamental right for gay people to marry, meaning that there will be no impact in the more than 30 states that do not recognize gay marriage.

The two cases, both decided on 5-4 votes, concerned the constitutionality of a key part of a federal law, the 1996 Defense of Marriage Act (DOMA), that denied benefits to same-sex married couples, and a voter-approved California state law enacted in 2008, called Proposition 8, that banned gay marriage.

The court struck down Section 3 of DOMA, which limited the definition of marriage as between a man and a woman for the purposes of federal benefits, as a violation of the U.S. Constitution's guarantee of equal protection under the law.

The ruling was a victory for President Barack Obama's administration, which had decided two years ago it would no longer defend the law in court. Obama applauded the DOMA ruling and directed U.S. Attorney General Eric Holder to review all relevant federal laws to ensure that it is implemented.

Justice Anthony Kennedy, 76, appointed to the court by Republican President Ronald Reagan in 1988, was the key vote and wrote the DOMA opinion, the third major gay rights ruling he has authored since 1996.

In a separate opinion, the court ducked a decision on Proposition 8 by finding that supporters of the California law did not have standing to appeal a federal district court ruling that struck it down. By doing so, the justices let stand the lower-court ruling that had found the ban unconstitutional.

Chief Justice John Roberts wrote the Proposition 8 opinion, ruling along procedural lines in a way that said nothing about how the court would rule on the merits. The court was unusually split, with liberals and conservatives in both the majority and the dissent.

By ruling this way on Proposition 8, the court effectively let states set their own policy on gay marriage. This means a debate is set to continue in various states via ballot initiatives, legislative action and litigation potentially costing millions of dollars on both sides of an issue that stirs cultural, religious and political passions in the United States as elsewhere.

The rulings come amid rapid progress for advocates of gay marriage in recent months and years. Opinion polls show a steady increase in U.S. public support for gay marriage.

'SECOND-CLASS CITIZENS'

Gay marriage advocates celebrated outside the courthouse. A big cheer went up as word arrived DOMA had been struck down. "DOMA is dead!" the crowd chanted, as couples hugged and cried.

Paul Katami and Jeffrey Zarrillo, a gay couple from Burbank, California, who were two of the four plaintiffs in the Proposition 8 case, were both outside the courthouse.

"We are gay. We are American. And we will not be treated like second-class citizens," Katami said.

He turned to Zarrillo, voice cracking and said: "I finally get to look at the man I love and say, 'Will you marry me?'"

Before Wednesday, 12 of the 50 U.S. states plus the District of Columbia recognized gay marriage. Three of those dozen - Delaware, Minnesota and Rhode Island - legalized gay marriage this year. California would become the 13th state to allow it.

About a third of the U.S. population now lives in areas where gay marriage is legal, if California is included.

"We are a people who declared that we are all created equal, and the love we commit to one another must be equal as well," Obama, the first sitting president to endorse gay marriage, said in a written statement.

While the ruling on DOMA was clearcut, questions remained about the meaning of the Proposition 8 ruling for California. Proposition 8 supporters vowed to seek continued enforcement of the ban until litigation is resolved. But California Governor Jerry Brown, a Democrat, said the justices' ruling "applies statewide" and all county officials must comply with it.

"We are now faced with this unusual situation where we have some uncertainty," said Andrew Pugno, one of the Proposition 8 proponents' lawyers. He expressed satisfaction that the Supreme Court had "nullified" a San Francisco-based 9th U.S. Circuit Court of Appeals ruling that, if left intact, could have had set a precedent for other Western states in its jurisdiction.

FEDERAL BENEFITS

By striking down Section 3 of DOMA, the court cleared the way for legally married couples to claim more than 1,100 federal benefits, rights and burdens linked to marriage status.

Kennedy wrote for the majority that the federal law, as passed by Congress, violated the U.S. Constitution's guarantee of equal protection. "The federal statute is invalid, for no legitimate purpose overcomes the purpose and effect to disparage and to injure those whom the state, by its marriage laws, sought to protect in personhood and dignity," Kennedy wrote.

The law imposed "a stigma upon all who enter into same-sex marriages made lawful by the unquestioned authority of the states," he said.

Roberts and Justice Antonin Scalia both wrote dissenting opinions in the DOMA case.

Roberts went out of his way to state that the court was not making any big pronouncements about gay marriage. The court, he said, did not have before it the question of whether states "may continue to utilize the traditional definition of marriage."

Scalia accused the majority of ignoring procedural obstacles about whether the court should have heard the case in order to reach its desired result.

"This is jaw-dropping," he said of Kennedy's analysis.

As a result of the DOMA ruling, Edith Windsor of New York, who was married to a woman and sued the government to get the federal estate tax deduction available to heterosexuals when their spouses die, will be able to claim a $363,000 tax refund.

The ruling was a win also for more than 200 businesses, including Goldman Sachs Group, Microsoft Corp and Google Inc, that signed on to a brief urging the court to strike down DOMA. Thomson Reuters Corp, owner of the Reuters news agency, was another signatory.

"Today's decisions help define who we are as a people, whether or not we are part of the group directly affected," said Lloyd Blankfein, Goldman's chief executive.

CHANGING LANDSCAPE

Numerous public figures including former President Bill Clinton, who in 1996 signed the DOMA law, and prominent groups including the American Academy of Pediatrics have come out this year in support of same-sex marriage and gay civil rights.

Individual members of Congress - Democrats and Republicans - also voiced new support for gay marriage this year.

Even with recent developments, there is still significant opposition among Republicans, including House of Representatives Speaker John Boehner, who had ordered the House to intervene in the DOMA case in defense of the law. Boehner said in a statement he was "obviously disappointed in the ruling" and predicted that a "robust national debate over marriage" would continue.

While more developments lie ahead, the legal fight over gay marriage already constitutes one of the most concentrated civil rights sagas in U.S. history.

Just 20 years ago, the Hawaii Supreme Court ruled that its state constitution could allow gay marriage, prompting a nationwide backlash and spurring Congress and a majority of states, including Hawaii, to pass laws defining marriage as between only a man and woman.

In 2003, when the top court of Massachusetts established a right to same-sex marriage under its constitution, the action triggered another backlash as states then adopted constitutional amendments against such unions. Five years later, the tide began to reverse, and states slowly began joining Massachusetts in permitting gays to marry.

The cases are United States v. Windsor, U.S. Supreme Court, No. 12-307 and Hollingsworth v. Perry, U.S. Supreme Court, No. 12-144.

(Additional reporting by Joseph Ax, Steve Holland and Roberta Rampton in Washington, Lauren Tara LaCapra in New York and Daniel Levine in San Francisco; Editing by Howard Goller and Will Dunham)

Source: http://news.yahoo.com/supreme-court-due-set-legal-course-gay-marriage-050417451.html

aaliyah jodie foster seahawks natalie wood patriots Sandy Hook Hoax 2014 Corvette

Feeling stressed? Oxytocin could help you reach out to others for support

June 25, 2013 ? The next time someone snubs you at a party and you think hiding is the solution to escape your feelings of rejection, think again. Scientists have shown that reaching out to other people during a stressful event is an effective way to improve your mood, and researchers at Concordia University suggest that the hormone oxytocin may help you accomplish just that.

Mark Ellenbogen and Christopher Cardoso, researchers in Concordia's Centre for Research in Human Development are taking a closer look at oxytocin, a hormone traditionally studied for its role in childbirth and breastfeeding, and more recently for its effect on social behaviour. Their latest study, published in the peer-reviewed journal Psychoneuroendocrinology, shows that oxytocin can increase a person's trust in others following social rejection.

Explains Ellenbogen, "that means that instead of the traditional 'fight or flight' response to social conflict where people get revved up to respond to a challenge or run away from it, oxytocin may promote the 'tend and befriend' response where people reach out to others for support after a stressful event. That can, in turn, strengthen social bonds and may be a healthier way to cope."

In a double-blind experiment, 100 students were administered either oxytocin or a placebo via a nasal spray, then subjected to social rejection. In a conversation that was staged to simulate real life, researchers posing as students disagreed with, interrupted and ignored the unsuspecting participants. Using mood and personality questionnaires, the data showed that participants who were particularly distressed after being snubbed by the researchers reported greater trust in other people if they sniffed oxytocin prior to the event, but not if they sniffed the placebo. In contrast, oxytocin had no effect on trust in those who were not emotionally affected by social rejection.

Cardoso, who is a doctoral student in the Department of Psychology, says that studying oxytocin may provide future options for those who suffer from mental health conditions characterized by high levels of stress and low levels of social support, like depression. "If someone is feeling very distressed, oxytocin could promote social support seeking, and that may be especially helpful to those individuals," he says, noting that people with depression tend to naturally withdraw even though reaching out to social support systems can alleviate depression and facilitate recovery.

For Ellenbogen, who holds a Canada Research Chair in Developmental Psychopathology, the contribution of stress the development of mood disorders like depression and bipolar disorder has long been a research focus. "I'm concerned with the biological underpinnings of stress, particularly interpersonal stress, which is thought to be a strong predictor of these mental disorders. So, oxytocin is a natural fit with my interests," says Ellenbogen. "The next phase of research will begin to study oxytocin's effects in those who are at high risk for developing clinical depression."

Cardoso says reactions to oxytocin seem to be more variable depending on individual differences and contextual factors than most pharmaceuticals, so learning more about how the hormone operates can help scientists to figure out how it might be used in future treatments.

"Previous studies have shown that natural oxytocin is higher in distressed people, but before this study nobody could say with certainty why that was the case," Cardoso says, "In distressed people, oxytocin may improve one's motivation to reach out to others for support. That idea is cause for a certain degree of excitement, both in the research community and for those who suffer from mood disorders."

Source: http://feeds.sciencedaily.com/~r/sciencedaily/living_well/~3/bFfgd4haaRI/130625092003.htm

birdsong teresa giudice atlanta hawks 2012 white house correspondents dinner forrest gump bernard hopkins devils

FDA gives go-ahead for two new cigarettes, rejects four

You expect rock stars to live insulated lives, with hardly any real idea of what's happening in the real world, but Mick Jagger, of all people, is always up on the day's big stories. The Rolling Stones were playing in D.C. last night, and the oldest surviving mega-frontman in rock and roll cracked wise at President Obama's expense. The Stones brought their 50 and Counting tour?to the Verizon Center in the nation's capital on Monday night for (potentially) their last show on U.S. soil, ever. (Unless they tour again, which, you know, these guys don't really age. ...

Source: http://news.yahoo.com/fda-gives-ahead-two-cigarettes-rejects-four-170904563.html

wonderlic test texas tornado fantasy baseball jared sullinger jaleel white levi johnston 2013 srt viper

Telecoupling pulls pieces of sustainability puzzle together

Public release date: 25-Jun-2013
[ | E-mail | Share ]

Contact: Sue Nichols
Nichols@msu.edu
517-432-0206
Michigan State University

Global sustainability is like a high-stakes jigsaw puzzle and an international group of scientists have created a new framework to assemble the big picture without losing pieces.

Scientists led by Jianguo "Jack" Liu, Michigan State University's Rachel Carson Chair in Sustainability, have built an integrated way to study a world that has become more connected with faster and more socioeconomic and environmental interactions over distances. They say "telecoupling" describes how distance is shrinking and connections are strengthening between nature and humans.

In Ecology and Society, Liu, director of MSU's Center for Systems Integration and Sustainability (CSIS), and his colleagues lay the groundwork to understand how an action on one side of the world has enormous socioeconomic and environmental consequences thousands of miles away and how it doesn't stop there. Telecoupling shows how environmental and socioeconomic actions lead to reactions and feedbacks and then to more repercussions that reverberate globally.

For a world struggling to balance the needs of people and the environment in the face of critical challenges like climate change, food security, water security, energy security, environmental pollution, poverty, biodiversity loss and species invasion, Liu says an integrated framework of telecoupling is essential.

"It has been traditional to focus on either the socioeconomic or environmental impact of an action," Liu said. "But the lack of a holistic understanding of an action means that you really cannot manage a system well for both socioeconomic and environmental sustainability.

The article "Framing Sustainability in a Telecoupled World" lays out a comprehensive telecoupling framework a map for the trip to sustainable development across the world.

The authors use the trading of soybeans as an example of the far-reaching complexities that result.

Soybeans are a booming commodity in China used for food, vegetable oil and animal feed. The telecoupling framework uses five components (systems, agents, flows, causes, and effects) critical to assembling the whole picture.

Systems are where humans and nature interact. Explosive growth and increasing urbanity has sent the Chinese shopping elsewhere for soybeans. Brazil has stepped up to the plate to meet the demands and has suffered environmental consequences as delicate rainforests are converted to farmland. China, on the other hand, has been converting farmlands back to forests.

The telecoupling framework tracks how one change leads to another and can spill over into other countries. For example, the United States found itself losing market share in soybeans, leading to economic repercussions and environmental changes as farmers shifted gears.

Flows are the materials, information and energy that pass back and forth between systems. China and Brazil have trade agreements, financial transactions and the use of fuel and water to grow and transport the beans.

The telecoupling framework also factors in the actions of agents the individuals, decision-make groups, or even herds of animals -- whose actions have an impact, big and small, what they do in China can resonate in Brazil and visa versa -- or somewhere in between.

Then there are causes and effects supply, demand and the cultural tastes that drive demand are among many causes. Effects can be the impact of insecticides and fertilizers used to grow the beans in Brazil or displacement of farmers in China who no longer grow soybeans due to the lower price of soybeans from Brazil.

Besides soybean trade, telecouplings may emerge through other types of trade, and other distant interactions such as foreign investment, tourism, transnational land tenure transfer, knowledge dissemination, technology transfer, migration of humans and animals, water transfer, waste transfer, pollutant transfer, atmospheric circulation, and species invasion.

The point, Liu said, is that everything everywhere needs to be factored in.

"This is a big step to figure out how to quantify everything everywhere, but it's important," Liu said. "The telecoupling framework not only allows us to understand socioeconomic and environmental sustainability in one place, but it enables us to evaluate sustainability in all relevant places simultaneously.

"It provides a useful foundation to protect our environment while allowing people to thrive globally."

###

Joining Liu in writing the article is Vanessa Hull, Thomas Dietz, Shuxin Li, William McConnell, Emilio Moran and Cynthia Simmons, all from MSU; Mateus Batistella from Brazil's EMBRAPA; Ruth DeFries of Columbia University; Feng Fu and Karen Polenske of MIT; Thomas Hertel of Purdue University; Roberto Izaurralde of the Joint Global Change Research Institute; Eric Lambin, Rosamond Naylor and Peter Vitousek of Stanford; Luiz Martinelli of the University of So Paulo, Brazil; Zhiyun Ouyang of the Chinese Academy of Sciences; Anette Reenberg of the University of Copenhagen; Gilberto Rocha of Federal University of Par, Brazil; Peter Verburg of VU University of Amsterdam; Fusuo Zhang of China Agricultural University and Chunquan Zhu of International Union for Conservation of Nature in China.

The work was funded by the National Science Foundation, U.S. Department of Energy, Michigan State University, and Michigan AgBioResearch.

---

[ | E-mail | Share ]

?

AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Public release date: 25-Jun-2013
[ | E-mail | Share ]

Contact: Sue Nichols
Nichols@msu.edu
517-432-0206
Michigan State University

Global sustainability is like a high-stakes jigsaw puzzle and an international group of scientists have created a new framework to assemble the big picture without losing pieces.

Scientists led by Jianguo "Jack" Liu, Michigan State University's Rachel Carson Chair in Sustainability, have built an integrated way to study a world that has become more connected with faster and more socioeconomic and environmental interactions over distances. They say "telecoupling" describes how distance is shrinking and connections are strengthening between nature and humans.

In Ecology and Society, Liu, director of MSU's Center for Systems Integration and Sustainability (CSIS), and his colleagues lay the groundwork to understand how an action on one side of the world has enormous socioeconomic and environmental consequences thousands of miles away and how it doesn't stop there. Telecoupling shows how environmental and socioeconomic actions lead to reactions and feedbacks and then to more repercussions that reverberate globally.

For a world struggling to balance the needs of people and the environment in the face of critical challenges like climate change, food security, water security, energy security, environmental pollution, poverty, biodiversity loss and species invasion, Liu says an integrated framework of telecoupling is essential.

"It has been traditional to focus on either the socioeconomic or environmental impact of an action," Liu said. "But the lack of a holistic understanding of an action means that you really cannot manage a system well for both socioeconomic and environmental sustainability.

The article "Framing Sustainability in a Telecoupled World" lays out a comprehensive telecoupling framework a map for the trip to sustainable development across the world.

The authors use the trading of soybeans as an example of the far-reaching complexities that result.

Soybeans are a booming commodity in China used for food, vegetable oil and animal feed. The telecoupling framework uses five components (systems, agents, flows, causes, and effects) critical to assembling the whole picture.

Systems are where humans and nature interact. Explosive growth and increasing urbanity has sent the Chinese shopping elsewhere for soybeans. Brazil has stepped up to the plate to meet the demands and has suffered environmental consequences as delicate rainforests are converted to farmland. China, on the other hand, has been converting farmlands back to forests.

The telecoupling framework tracks how one change leads to another and can spill over into other countries. For example, the United States found itself losing market share in soybeans, leading to economic repercussions and environmental changes as farmers shifted gears.

Flows are the materials, information and energy that pass back and forth between systems. China and Brazil have trade agreements, financial transactions and the use of fuel and water to grow and transport the beans.

The telecoupling framework also factors in the actions of agents the individuals, decision-make groups, or even herds of animals -- whose actions have an impact, big and small, what they do in China can resonate in Brazil and visa versa -- or somewhere in between.

Then there are causes and effects supply, demand and the cultural tastes that drive demand are among many causes. Effects can be the impact of insecticides and fertilizers used to grow the beans in Brazil or displacement of farmers in China who no longer grow soybeans due to the lower price of soybeans from Brazil.

Besides soybean trade, telecouplings may emerge through other types of trade, and other distant interactions such as foreign investment, tourism, transnational land tenure transfer, knowledge dissemination, technology transfer, migration of humans and animals, water transfer, waste transfer, pollutant transfer, atmospheric circulation, and species invasion.

The point, Liu said, is that everything everywhere needs to be factored in.

"This is a big step to figure out how to quantify everything everywhere, but it's important," Liu said. "The telecoupling framework not only allows us to understand socioeconomic and environmental sustainability in one place, but it enables us to evaluate sustainability in all relevant places simultaneously.

"It provides a useful foundation to protect our environment while allowing people to thrive globally."

###

Joining Liu in writing the article is Vanessa Hull, Thomas Dietz, Shuxin Li, William McConnell, Emilio Moran and Cynthia Simmons, all from MSU; Mateus Batistella from Brazil's EMBRAPA; Ruth DeFries of Columbia University; Feng Fu and Karen Polenske of MIT; Thomas Hertel of Purdue University; Roberto Izaurralde of the Joint Global Change Research Institute; Eric Lambin, Rosamond Naylor and Peter Vitousek of Stanford; Luiz Martinelli of the University of So Paulo, Brazil; Zhiyun Ouyang of the Chinese Academy of Sciences; Anette Reenberg of the University of Copenhagen; Gilberto Rocha of Federal University of Par, Brazil; Peter Verburg of VU University of Amsterdam; Fusuo Zhang of China Agricultural University and Chunquan Zhu of International Union for Conservation of Nature in China.

The work was funded by the National Science Foundation, U.S. Department of Energy, Michigan State University, and Michigan AgBioResearch.

---

[ | E-mail | Share ]

?

AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Source: http://www.eurekalert.org/pub_releases/2013-06/msu-tpp062513.php

i robot the big c the visitor king of kings ostara masters 2012 andy kaufman

Turkish Police Shoot Down Drone As It Flies Over Protestors

As personal drones become more usable - and more ubiquitous - I think we'll see more and more scenes like this one. The video, taken in Istanbul by a protester named Jenk Kose, shows the quadcopter falling out of the sky after being shot at by the police. The quadcopter's camera failed when it was hit but Jenk was able to save some of the footage.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/0PjNWVBE9xQ/

VP debate sandusky Sam Champion Hulk Hogan sex tape orioles Sarah Jones chicago marathon